Ketamine-induced NMDA receptor blockade during natural speech production and Its implications for formal thought disorder in schizophrenia: A Pharmaco-fMRI Study

Abstract Structural and functional changes in the lateral temporal language areas have been related to formal thought disorder (FTD) in schizophrenia. Continuous, natural speech production activates the right lateral temporal lobe in schizophrenia, as opposed to the left in healthy subjects. Positive and negative FTD can be elicited in healthy subjects by glutamatergic NMDA blockade […]

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