2022

Determinants of motivated behavior are linked to fatigue and its perturbation by SARS-CoV-2 vaccination

2022, Clinical, Social Learning /

Abstract Background Fatigue has an adaptive function and serves as a temporary signal to rest and save energy often in response to immune activation. It may, however, also persist in a pathological condition incurring significant burden. While subjective symptoms and scientific consensus indicate that both physical and mental determinants of motivated behavior are affected in fatigue, […]

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The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic

2022, Hormones/Neuromodulators /

Abstract Twenty-four-hour rhythms in immune parameters and functions are robustly observed phenomena in biomedicine. Here, we summarize the important role of sleep and associated parameters on the neuroendocrine regulation of rhythmic immune cell traffic to different compartments, with a focus on human leukocyte subsets. Blood counts of “stress leukocytes” such as neutrophils, natural killer cells,

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