bioRxiv

No support for oxytocin modulation of reward-related brain function in autism: evidence from a randomized controlled trial

Abstract Autism spectrum disorder (ASD) is characterized by difficulties in social communication and interaction, which have been related to atypical neural processing of rewards, especially in the social domain. Since intranasal oxytocin has been shown to modulate activation of the brain’s reward circuit, oxytocin could be a useful tool to ameliorate the processing of social …

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Association of stress-related limbic activity and baseline interleukin-6 plasma levels in healthy adults

Abstract There is a bidirectional interaction between peripheral inflammatory processes and the brain. In the context of stress, top-down effects on the immune system have already been studied, but bottom-up effects of peripheral inflammation on neural processes are still unclear. In the present study, baseline plasma levels of the cytokine interleukin (IL)-6 were obtained as …

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Reduced frontal cortical tracking of conflict between selfish versus prosocial motives in Narcissistic Personality Disorder

Abstract Abstract Narcissistic Personality Disorder (NPD) entails severe impariments in interpersonal functioning that are likely driven by selfish and exploitative behavior. Here, we investigate the underlying motivational and neural mechanisms of prosocial decision-making by experimentally manipulating motivational conflict between selfish and prosocial incentives. One group of patients diagnosed with NPD and a group of healthy …

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Self-beneficial belief updating as a coping mechanism for stress-induced negative affect

Abstract Being confronted with social-evaluative stress elicits a physiological and a psychological stress response. This calls for regulatory processes to manage negative affect and maintain self-related optimistic beliefs. The aim of the current study was to investigate the affect-regulating potential of self-related belief updating after exposure to social-evaluative stress, in comparison to non-social physical stress …

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