Clinical

Contracted functional connectivity profiles in autism

2024, Clinical /

A new publication by Clara F. Weber from her time at the Multimodal Imaging and Connectome Analysis Laboratory (head: Prof Boris Bernhardt) at the Montreal Neurological Institute, McGill University in Canada.    Objective Autism spectrum disorder (ASD) is a neurodevelopmental condition that is associated with atypical brain network organization, with prior work suggesting differential connectivity […]

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Altered physiological, affective, and functional connectivity responses to acute stress in patients with alcohol use disorder

2024, Clinical, Hormones/Neuromodulators /

Background There is evidence that the processing of acute stress is altered in alcohol use disorder (AUD), but little is known about how this is manifested simultaneously across different stress parameters and which neural processes are involved. The present study examined physiological and affective responses to stress and functional connectivity in AUD. Methods Salivary cortisol

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Your smile won’t affect me: Association between childhood maternal antipathy and adult neural reward function in a transdiagnostic sample

2023, Clinical, Publications /

Abstract Aberrant activation in the ventral striatum (VS) during reward anticipation may be a key mechanism linking adverse childhood experiences (ACE) to transdiagnostic psychopathology. This study aimed to elucidate whether retrospectively reported ACE, specifically maternal antipathy, relate to monetary and social reward anticipation in a transdiagnostic adult sample. A cross-sectional neuroimaging study was conducted in

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The (un)learning of social functions and its significance for mental health

2022, Clinical, Social Learning /

Abstract Social interactions are dynamic, context-dependent, and reciprocal events that influence prospective strategies and require constant practice and adaptation. This complexity of social interactions creates several research challenges. We propose a new framework encouraging future research to investigate not only individual differences in capacities relevant for social functioning and their underlying mechanisms, but also the

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Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity

2022, Clinical /

Abstract Most patients with Post COVID Syndrome (PCS) present with a plethora of symptoms without clear evidence of organ dysfunction. A subset of them fulfills diagnostic criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Symptom severity of ME/CFS correlates with natural regulatory autoantibody (AAB) levels targeting several G-protein coupled receptors (GPCR). In this exploratory study, we

Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity Read More »

Age-dependent white matter microstructural disintegrity in autism spectrum disorder

2022, Clinical /

Abstract There has been increasing evidence of White Matter (WM) microstructural disintegrity and connectome disruption in Autism Spectrum Disorder (ASD). We evaluated the effects of age on WM microstructure by examining Diffusion Tensor Imaging (DTI) metrics and connectome Edge Density (ED) in a large dataset of ASD and control patients from different age cohorts. N = 583

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Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders

2022, Clinical /

Abstract This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four

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Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains.

2022, Clinical /

Abstract Accelerated maturation of brain parenchyma close to term-equivalent age leads to rapid changes in diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) metrics of neonatal brains, which can complicate the evaluation and interpretation of these scans. In this study, we characterized the topography of age-related evolution of diffusion metrics in neonatal brains. We included

Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains. Read More »

Determinants of motivated behavior are linked to fatigue and its perturbation by SARS-CoV-2 vaccination

2022, Clinical, Social Learning /

Abstract Background Fatigue has an adaptive function and serves as a temporary signal to rest and save energy often in response to immune activation. It may, however, also persist in a pathological condition incurring significant burden. While subjective symptoms and scientific consensus indicate that both physical and mental determinants of motivated behavior are affected in fatigue,

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Assessment of reward-related brain function after a single-dose of oxytocin in autism: a randomized controlled trial

2021, Clinical, Hormones/Neuromodulators, Social Reward /

Background Autism spectrum disorder (ASD) is characterized by difficulties in social communication and interaction, which have been related to atypical neural processing of rewards, especially in the social domain. Since intranasal oxytocin has been shown to modulate activation of the brain’s reward circuit, oxytocin might ameliorate the processing of social rewards in ASD and thus

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