Sören Krach

New publication out in Human Brain Mapping!

Abstract Accelerated maturation of brain parenchyma close to term-equivalent age leads to rapid changes in diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) metrics of neonatal brains, which can complicate the evaluation and interpretation of these scans. In this study, we characterized the topography of age-related evolution of diffusion metrics in neonatal brains. We included …

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New publication out in Human Brain Mapping!

“Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains” by Pratheek S. Bobba, Clara F. Weber et al., 2022 Very cool new publication by our PhD student Clara F. Weber! Congratulations!   Bobba, P. S., Weber, C. F., Mak, A., Mozayan, A., Malhotra, A., Sheth, K. N., Taylor, S. N., Vossough, A., Grant, P. E., Scheinost, D., Constable, R. T., Ment, L. R., & Payabvash, S. (2022). Age-related …

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Determinants of motivated behavior are linked to fatigue and its perturbation by SARS-CoV-2 vaccination

New preprint out! In this very collaborative research project, we assessed the impact of a SARS-CoV-2 vaccination on determinants of motivated behavior: mental and physical exhaustion. To do so, we made use of a novel experimental paradigm (developed and extensively piloted by first author David S. Stolz), the Learn/Effort-task, to quantify these sub-facets of motivated …

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Determinants of motivated behavior are linked to fatigue and its perturbation by SARS-CoV-2 vaccination

Abstract Background Fatigue has an adaptive function and serves as a temporary signal to rest and save energy often in response to immune activation. It may, however, also persist in a pathological condition incurring significant burden. While subjective symptoms and scientific consensus indicate that both physical and mental determinants of motivated behavior are affected in fatigue, …

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The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic

Abstract Twenty-four-hour rhythms in immune parameters and functions are robustly observed phenomena in biomedicine. Here, we summarize the important role of sleep and associated parameters on the neuroendocrine regulation of rhythmic immune cell traffic to different compartments, with a focus on human leukocyte subsets. Blood counts of “stress leukocytes” such as neutrophils, natural killer cells, …

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New collaborative publication with the PNI out!

The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic The first cooperative paper between the Social Neuroscience Lab and Psychoneuroimmunology (Prof. Tanja Lange; Department of Rheumatology & Clinical Immunology) is out!  In our review, we summarize how 24-h rhythms in leukocyte traffic are regulated by neuroendocrine mediators and how this is supported by …

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Lab visit by Geert-Jan Will

Today, we had a spectacular visit by Geert-Jan Will from Utrecht University who presented his research on the computational mechanisms of self-esteem formation and its relevance for psychiatric conditions. Moreover, we took advantage of the situation (first real-life lab visit after 1.5 years) to discuss links between self-related belief formation, affect, subjectively perceived control, effort exertion, …

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New publication out in Biological Psychiatry: GOS!

“Assessment of reward-related brain function after a single-dose of oxytocin in autism: a randomized controlled trial.” Mayer et al., 2021 A long journey comes to an end! After initial discussions at Marburg University about a potential German-wide autism research net back in 2012, with the first draft being submitted in 2013, being granted the BMBF-funded …

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Neurocomputational mechanisms of affected beliefs

Abstract The feedback people receive on their behavior shapes the process of belief formation and self-efficacy in mastering a given task. The neural and computational mechanisms of how the subjective value of these beliefs and corresponding affect bias the learning process are yet unclear. Here we investigate this question during learning of self-efficacy beliefs using …

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